Вика,Galka0103 Да собственно, не за что благодарить, у меня просто многие зарубежные сайты(клубы, питомники) лежат в закладках и я переодически отслеживаю новости, делов то -скопировал, вставил.

Новую тему заводить не буду, скопирую отчет:

Mini health symposium  Cairn Terriers in the Netherlands, 2 September 2011

In the context of its 60th Anniversary the NCTC organised a mini health symposium "Cairn Terriers in the Netherlands" at the Leisure Centre Erkemederstrand near Zeewolde. Two subjects were presented: progress of research into the hereditary effects of Portosystemic Shunt by Mr Frank van Steenbeek, and behanviour and social environment by Ms Nienke Endenburg. Both are working at the Veterinary Faculty of Utrecht University. Presentations were made in Dutch and English. We welcomed more than 80 participants and also from Belgium, Germany, Finland, Russia and the UK.

Extrahepatic portosystemic shunts in Cairn Terriers - an update

The first part of the presentation was made by  Lindsay van de Bossche, a student veterenary medicin at Utrecht University:

The disease
A portosystemic shunt is a congenital hereditary abnormality of the vascular system in which a connection occurs between the portal vein and the vena cava. This connection is obtained by an additional vessel, which can be located in (intrahepatic) or around (extrahepatic) the liver. Approximately 1% of the Cairn terriers is affected by a portosystemic shunt, the extrahepatic type is most commonly observed in this breed.
In the presence of a shunt, the liver function is reduced and as a consequence the liver can not discard absorbed toxins from the blood, like ammonia. These toxins will accumulate and cause clinical signs, whereby the signs of a disturbed brain function will predominate. The clinical signs can be observed in varying degrees and occur intermittently. Therefore it is not possible to diagnose a shunt based on clinical signs only.
The age at onset of clinical signs due to a portosystemic shunt varies among dogs; from several months to years. The observation of an elevated blood ammonia level proves the presence of a shunt. The definitive diagnosis can be performed through visualization of the shunt by ultrasonography or a CT-scan. Unfortunately, a portosystemic shunt is a disease that can not be solved by it self. The clinical signs will worsen over time. If no treatment is applied, the disease can be lethal. Permanent recovery can be obtained by surgical attenuation of the shunt. When is decided not to operate the dog, euthanasia is often the remaining option.

Frank van Steenbeek, a Phd Student at the Veterenary Faculty of Utrecht University, then went on to present the progress of the:

Genetic study
Since 2005 the genome of the dog became public available. Thanks to the help of the boxer Tasha the sequence of “the dog” was determined. This sequence contains several differences when compared with the genome of other breeds, but is very useful as a reference in research.
Back in 2008 the European Union started a project in which they intent to use the dog as a model for complex genetic human diseases. Utrecht University participates in this project with research on the disease extrahepatic shunts. Thanks to many years of fruitful cooperation between University and the Dutch Cairn Terrier Club blood was collected of most of the affected Cairn terriers diagnosed last years. Of these samples DNA was isolated. With this DNA and that of healthy Cairn terriers an extensive experiment was conducted. In this experiment about 50.000 positions on the dog genome have been investigated. For all these position affected dogs were checked whether they gave mutual results and differed from the healthy dogs. This experiment resulted in three relatively large genomic regions.
Following experiments reduced these regions to two smaller genomic regions. These regions have been examined in other breeds affected with extrahepatic shunts. Since breed formation is relatively young and the phenotype shows full resemblance between all breeds we are convinced that all breeds should share the same mutations. Most of these breeds show overlap with the positive results of the DNA study ensuring the regions to be very promising. The following period a lot of work will be done to reduce the regions even more. Hopefully this will lead to adequate information resulting in a solid DNA test in the near future.

это ссыль на Недерландский керн клуб,откуда скопировано: http://www.nctc.nl/index.php?pid=166

Отредактировано ВЭТ (Суббота, 1 октября, 2011г. 17:20:14)